I have had this problem a couple of times with my cadet. If its anything like mine it is probably a blockage/contamination on one of the ink tubes.
basically all i did was clear the blockage and print out about 1500mm of each main colour. i.e. cyan, yellow, black & blue until it eventually clears itself and the colours come back to life.
when you say tried loads of profiles. Do you mean you have made these profiles yourself or just used generic pre-made profiles. As you are probably aware each ink/paper/resolution require a new profile for best results.
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